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Ca²⁺-induced delayed afterdepolarizations are triggered by dyadic subspace Ca2²⁺ affirming that increasing SERCA reduces aftercontractions.

Abstract:

Ca(2+)-induced delayed afterdepolarizations (DADs) are depolarizations that occur after full repolarization. They have been observed across multiple species and cell types. Experimental results have indicated that the main cause of DADs is Ca(2+) overload. The main hypothesis as to their initiation has been Ca(2+) overflow from the overloaded sarcoplasmic reticulum (SR). Our results using 37 previously published mathematical models provide evidence that Ca(2+)-induced DADs are initiated by th...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.01055.2010

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
301
Issue:
3
Pages:
H921-H935
Publication date:
2011-09-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:2966b254-66e9-43a4-b465-244419e3def2
Source identifiers:
237566
Local pid:
pubs:237566

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