Journal article icon

Journal article

Potential role of a sperm-derived phospholipase C in triggering the egg-activating Ca2+ signal at fertilization.

Abstract:

An increase in intracellular Ca2+ at fertilization is the trigger for egg activation in all species that have been studied. Exactly how sperm-egg interaction leads to this Ca2+ increase has not been established. There is increasing support for the hypothesis that the spermatozoon introduces a Ca2+-releasing protein into the egg cytoplasm after gamete membrane fusion. This review discusses the merits of this 'sperm factor' hypothesis and presents evidence indicating that the sperm factor, at l...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1530/rep.0.1220839

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Reproduction (Cambridge, England)
Volume:
122
Issue:
6
Pages:
839-846
Publication date:
2001-12-05
DOI:
EISSN:
1741-7899
ISSN:
1470-1626
URN:
uuid:294e56e8-bbe0-4290-b008-e575d52c4a7d
Source identifiers:
185173
Local pid:
pubs:185173

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP