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Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma.

Abstract:

RPTPsigma is a cell adhesion molecule-like receptor protein tyrosine phosphatase involved in nervous system development. Its avian orthologue, known as cPTPsigma or CRYPalpha, promotes intraretinal axon growth and controls the morphology of growth cones. The molecular mechanisms underlying the functions of cPTPsigma are still to be determined, since neither its physiological ligand(s) nor its substrates have been described. Nevertheless, a major class of ligand(s) is present in the retinal ba...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
McKinnell, IW More by this author
Halfter, W More by this author
Stoker, AW More by this author
Journal:
Molecular and cellular biology
Volume:
22
Issue:
6
Pages:
1881-1892
Publication date:
2002-03-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:294bd8d8-8d20-43be-b978-93b1a949de96
Source identifiers:
14368
Local pid:
pubs:14368

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