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Compound exocytosis in voltage-clamped mouse pancreatic beta-cells revealed by carbon fibre amperometry.

Abstract:

Capacitance measurements of exocytosis were combined with carbon fibre amperometry for time-resolved measurements of the properties of secretion in single, insulin-secreting, mouse pancreatic beta-cells pre-loaded with the amine serotonin (5-HT). Glucose-induced electrical activity was associated with the appearance of brief and transient amperometric currents reflecting the serotonin co-released with insulin. The integrated amperometric responses resulting from voltage-clamp depolarisations ...

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Publication status:
Published

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Publisher copy:
10.1007/s004240050987

Authors


Bokvist, K More by this author
Holmqvist, M More by this author
Gromada, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Pflugers Archiv : European journal of physiology
Volume:
439
Issue:
5
Pages:
634-645
Publication date:
2000-03-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:2947aa60-3bb1-4e38-b9dc-352fb99304d1
Source identifiers:
21747
Local pid:
pubs:21747

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