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Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

Abstract:

Fluorescent base analogues (FBAs) have emerged as a powerful class of molecular reporters of location and environment for nucleic acids. In our overall mission to develop bright and useful FBAs for all natural nucleobases, herein we describe the synthesis and thorough characterization of bicyclic thymidine (bT), both as a monomer and when incorporated into DNA. We have developed a robust synthetic route for the preparation of the bT DNA monomer and the corresponding protected phosphoramidite ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-018-31897-2

Authors


Lawson, CP More by this author
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ORCID:
0000-0003-0223-5754
Wranne, MS More by this author
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Carl Tryggers Stiftelse More from this funder
Swedish Research Council More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Issue:
1
Pages:
13970
Publication date:
2018-09-18
Acceptance date:
2018-08-23
DOI:
EISSN:
2045-2322
Pubs id:
pubs:920994
URN:
uri:2942b3db-476f-46d6-857b-8d8385a74830
UUID:
uuid:2942b3db-476f-46d6-857b-8d8385a74830
Local pid:
pubs:920994
Language:
English
Keywords:

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