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Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial.

Abstract:

BACKGROUND: Antidepressants exhibit a variety of pharmacological actions including inhibition of the serotonin and noradrenaline transporters. We wished to investigate whether genetic variation could be used to target or personalise treatment, in a comparison of selective serotonin reuptake inhibitors (SSRIs) with noradrenaline reuptake inhibitors (NARIs). AIMS: To test the hypothesis that patients homozygous for the long (insertion) polymorphism of the serotonin transporter (5-HTTLPR) have a...

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Publication status:
Published

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Publisher copy:
10.1192/bjp.bp.110.082727

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Journal:
British journal of psychiatry : the journal of mental science
Volume:
198
Issue:
6
Pages:
464-471
Publication date:
2011-06-01
DOI:
EISSN:
1472-1465
ISSN:
0007-1250
Source identifiers:
159415

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