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Safety and efficacy of iron therapy on reducing red blood cell transfusion requirements and treating anaemia in critically ill adults: A systematic review with meta-analysis and trial sequential analysis

Abstract:
Purpose To evaluate the safety (risk of infection) and efficacy (transfusion requirements, changes in haemoglobin (Hb)) of iron therapy in adult intensive care unit (ICU) patients.

Materials and methods We systematically searched seven databases for all relevant studies until January 2018 and included randomized (RCT) studies comparing iron, by any route, with placebo/no iron.

Results 805 participants from 6 RCTs were in... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jcrc.2018.11.005

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
Oxford college:
Lady Margaret Hall
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Department of Clinical Neurosciences
Expand authors...
Publisher:
Elsevier Publisher's website
Journal:
Journal of Critical Care Journal website
Volume:
49
Pages:
162-171
Publication date:
2018-11-10
Acceptance date:
2018-11-10
DOI:
EISSN:
1557-8615
ISSN:
0883-9441
Pubs id:
pubs:943970
URN:
uri:292d261e-0260-4d20-a770-2379ec126bbb
UUID:
uuid:292d261e-0260-4d20-a770-2379ec126bbb
Local pid:
pubs:943970

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