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A Small Molecule Inhibitor of PDK1/PLCγ 31 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Abstract:

Strong evidence suggests that phospholipase Cγ 31 (PLCγ 31) is a suitable target to counteract tumourigenesis and metastasis dissemination. We recently identified a novel signalling pathway required for PLCγ 31 activation which involves formation of a protein complex with 3-phosphoinositide-dependent protein kinase 1 (PDK1). In an effort to define novel strategies to inhibit PLCγ 31-dependent signals we tested here whether a newly identified and highly specific PDK1 inhibitor, 2-O-benzyl-myo-...

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Publication status:
Published

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Publisher copy:
10.1038/srep26142

Authors


Raimondi, C More by this author
Calleja, V More by this author
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Department:
Default/Not Applicable
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Journal:
Scientific Reports
Publication date:
2016-05-20
DOI:
ISSN:
2045-2322
Pubs id:
pubs:630480
URN:
uri:29281f7d-21e4-41a7-8b5b-32a2636b43a6
UUID:
29281f7d-21e4-41a7-8b5b-32a2636b43a6
Local pid:
pubs:630480
Language:
English
Keywords:

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