Journal article icon

Journal article

In vitro functional effects of XPC gene rare variants from bladder cancer patients.

Abstract:

The XPC gene is involved in repair of bulky DNA adducts formed by carcinogenic metabolites and oxidative DNA damage, both known bladder cancer risk factors. Single nucleotide polymorphisms (SNPs) in XPC have been associated with increased bladder cancer risk. Recently, rarer genetic variants have been identified but it is difficult to ascertain which are of functional importance. During a mutation screen of XPC in DNA from 33 bladder tumour samples and matched blood samples, we identified fiv...

Expand abstract
Publication status:
Published

Actions


Access Document


Files:
Publisher copy:
10.1093/carcin/bgr005

Authors


Ansari, AH More by this author
Chambers, PA More by this author
Expand authors...
Journal:
Carcinogenesis
Volume:
32
Issue:
4
Pages:
516-521
Publication date:
2011-04-05
DOI:
EISSN:
1460-2180
ISSN:
0143-3334
URN:
uuid:2927b4c0-f1c9-4c3e-8eb9-ed11b9eea94f
Source identifiers:
130830
Local pid:
pubs:130830

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP