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Journal article

Primary lateral sclerosis: consensus diagnostic criteria

Abstract:

Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system. Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is clinical, after exclusion of structural, neurodegenerative and metabolic mimics. Differentiation of PLS from upper motor neuron-predominant forms of amyotrophic lateral sclerosis remains a significant challenge in the early symptomatic phase of both disorders, with ongoing debate as to whether they form a clinical and hi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0003-0267-3180
More from this funder
Name:
Motor Neurone Disease Association
Grant:
TURNER/OCT18/989-797
Publisher:
BMJ Publishing Group
Journal:
Journal of Neurology, Neurosurgery, and Psychiatry More from this journal
Volume:
91
Issue:
4
Pages:
373-377
Place of publication:
England
Publication date:
2020-02-06
Acceptance date:
2019-12-27
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Pmid:
32029539
Language:
English
Keywords:
Pubs id:
1087211
Local pid:
pubs:1087211
Deposit date:
2020-03-23

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