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The impact of memory T cells on rejection and the induction of tolerance.

Abstract:

Accumulating evidence suggests that alloreactive memory T cells (Tm) may be generated in transplant recipients that have not previously been exposed to alloantigen through mechanisms such as cross-reactivity and homeostatic proliferation. The presence of Tm correlates with both acute and chronic rejection episodes and, furthermore, may be responsible for the failure to induce tolerance in large animal and clinical settings. A clearer understanding of how Tm function and their requirements to ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
Transplantation
Volume:
82
Issue:
1
Pages:
1-9
Publication date:
2006-07-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:291bdf97-a70d-4a93-b575-771f0ae6058b
Source identifiers:
136020
Local pid:
pubs:136020

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