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Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP.

Abstract:

A recently identified membrane-type 6 matrix metalloproteinase (MT6-MMP) has a hydrophobic stretch of 24 amino acids at the C-terminus. This hydrophobicity pattern is similar to glycosyl-phosphatidyl inositol (GPI)-anchored MMP, MT4-MMP, and other GPI-anchored proteins. Thus, we tested the possibility that MT6-MMP was also a GPI-anchored proteinase. Our results showed that MT6-MMP as well as MT4-MMP were labeled with [3H]ethanolamine indicating the presence of a GPI unit with incorporated lab...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Matsumoto, S More by this author
Journal:
FEBS letters
Volume:
480
Issue:
2-3
Pages:
142-146
Publication date:
2000-09-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:29159d7d-df89-45ea-837e-2fda78257c21
Source identifiers:
224284
Local pid:
pubs:224284

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