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Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload.

Abstract:

Late sodium current in cardiac cells is very small compared with the fast component, but as it flows throughout the action potential it may make a substantial contribution to sodium loading during each cardiac cycle. Late sodium current may contribute to triggering arrhythmia in two ways: by causing repolarisation failure (early after depolarisations); and by triggering late after depolarisations attributable to calcium oscillations in sodium-calcium overload conditions. Reduction of late sod...

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Publication status:
Published

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Publisher copy:
10.1136/hrt.2005.078782

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Heart (British Cardiac Society)
Volume:
92 Suppl 4
Issue:
suppl_4
Pages:
iv1-iv5
Publication date:
2006-07-05
DOI:
EISSN:
1468-201X
ISSN:
1355-6037
URN:
uuid:29138bfe-3460-4a9b-9c98-d8da7e73b3ae
Source identifiers:
237835
Local pid:
pubs:237835

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