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Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.

Abstract:

BACKGROUND: Many patients with familial adenomatous polyposis (FAP) die from desmoid tumours which can arise spontaneously but often appear to be surgically induced by prophylactic colectomy. FAP results from germline adenomatous polyposis coli (APC) gene mutations and desmoids arise following biallelic APC mutation, with one change usually occurring distal to the second beta-catenin binding/degradation repeat of the gene (3' to codon 1399). We have suggested that because families with germl...

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Publisher copy:
10.1136/gut.2004.042705

Authors


Gallagher, MC More by this author
Bassett, P More by this author
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Journal:
Gut
Volume:
53
Issue:
12
Pages:
1832-1836
Publication date:
2004-12-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:28f96465-6eeb-4a7f-969e-9230be0ef86b
Source identifiers:
72227
Local pid:
pubs:72227

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