Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.

Journal article

Although bone marrow (BM) is the main site of natural killer (NK)-cell development in adult mice, recent studies have identified a distinct thymic-dependent NK pathway, implicating a possible close link between NK- and T-cell development in adult hematopoiesis. To investigate whether a potential NK-/T-lineage restriction of multipotent progenitors might take place already in the BM, we tested the full lineage potentials of NK-cell progenitors in adult BM. Notably, although Lin(-)CD122(+)NK1.1...

Expand abstract

Authors: Nozad Charoudeh, H; Tang, Y; Cheng, M; Cilio, C; Jacobsen, SE

• Publication status: Published
• Journal: Blood
• Volume: 116
• Issue: 2
• Pages: 183-192
• Publication date: 2010-07-01
• DOI: 10.1182/blood-2009-10-247130
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Bone Marrow Cells; T-Lymphocytes; Multipotent Stem Cells; Cell Separation; Hematopoietic Stem Cells; Flow Cytometry; Killer Cells, Natural; Mice, Inbred C57BL; Cell Lineage; Reverse Transcriptase Polymerase Chain Reaction; Mice; Animals; Hematopoiesis; Thymus Gland; Cell Differentiation