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Mycobacterium tuberculosis modulates miR-106b-5p to control cathepsin S expression resulting in higher pathogen survival and poor T-cell activation

Abstract:

The success of tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), relies on the ability to survive in host cells and escape to immune surveillance and activation. We recently demonstrated that Mtb manipulation of host lysosomal cathepsins in macrophages leads to decreased enzymatic activity and pathogen survival. In addition, while searching for microRNAs (miRNAs) involved in posttranscriptional gene regulation during mycobacteria infection of human macrophages, we found that selec...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2017.01819

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Role:
Author
ORCID:
0000-0001-9602-1516
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Issue:
DEC
Pages:
1819
Publication date:
2017-12-18
Acceptance date:
2017-12-04
DOI:
EISSN:
1664-3224
ISSN:
1664-3224
Pubs id:
pubs:895450
URN:
uri:28db5c2a-de82-48ef-b133-26de8c62adc8
UUID:
uuid:28db5c2a-de82-48ef-b133-26de8c62adc8
Local pid:
pubs:895450

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