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Identification of SPARC-like 1 protein as part of a biomarker panel for Alzheimer's disease in cerebrospinal fluid.

Abstract:

We have used proteomic fingerprinting to investigate diagnosis of Alzheimer's disease (AD). Samples of lumbar cerebrospinal fluid (CSF) from clinically-diagnosed AD cases (n = 33), age-matched controls (n = 20), and mild cognitive impairment (MCI) patients (n = 10) were used to obtain proteomic profiles, followed by bioinformatic analysis that generated a set of potential biomarkers in CSF samples that could discriminate AD cases from controls. The identity of the biomarker ions was determine...

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Publication status:
Published

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Publisher copy:
10.3233/jad-2011-111505

Authors


Vafadar-Isfahani, B More by this author
Coveney, C More by this author
Lemetre, C More by this author
Boocock, D More by this author
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Journal:
Journal of Alzheimer's disease : JAD
Volume:
28
Issue:
3
Pages:
625-636
Publication date:
2012
DOI:
EISSN:
1875-8908
ISSN:
1387-2877
URN:
uuid:28d40780-f937-42de-8c5b-43b5a057cfe7
Source identifiers:
317160
Local pid:
pubs:317160

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