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The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

Abstract:

BACKGROUND and AIMS: We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/degradation repeats (20AARs); very few intestinal tumors have proteins with no 20AARs. The coselection of the "2 hits" at APC makes it difficult to undertake further mechanisti...

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Publication status:
Published

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Journal:
Gastroenterology
Volume:
136
Issue:
7
Pages:
2204-2213.e1-13
Publication date:
2009-06-05
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
URN:
uuid:28cd338b-21d9-4a2a-b7b0-e8603b9f5c6c
Source identifiers:
41179
Local pid:
pubs:41179

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