Journal article icon

Journal article

Mechanism of immune complex-mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon-gamma and tumor necrosis factor-alpha.

Abstract:

The ability of immune complexes derived from patients with type II mixed essential cryoglobulinemia to trigger the production of interleukin 1 (IL 1) was investigated. Immune complexes containing either IgM/IgG or IgA/IgG aggregates were shown to induce IL 1 production in human peripheral blood monocyte-enriched populations. Interferon-gamma alone did not induce detectable IL 1, but increased the IL 1 production induced by the immune complexes. Tumor necrosis factor-alpha, which is a potent i...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/eji.1830190130

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
European journal of immunology
Volume:
19
Issue:
1
Pages:
189-192
Publication date:
1989-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:28c8ac91-ef3b-4bf0-ad18-c41d904ce050
Source identifiers:
481777
Local pid:
pubs:481777

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP