No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies.

Journal article

OBJECTIVE: The cytotoxic T lymphocyte associated-4 (CTLA-4) gene is a candidate for T-cell mediated autoimmune disease and polymorphism has been reported to be associated with both type 1 diabetes and autoimmune thyroid disease. A previously unreported polymorphism of the promoter region of the human CTLA-4 gene has recently been described in a sample of a normal control population. We investigated the distribution of this polymorphism, situated at position -318 to the ATG start codon and re...

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Authors: Heward, J; Allahabadia, A; Carr-Smith, J; Daykin, J; Cockram, C

• Journal: Clinical endocrinology
• Volume: 49
• Issue: 3
• Pages: 331-334
• Publication date: 1998-09-01
• DOI: 10.1046/j.1365-2265.1998.00542.x
• EISSN: 1365-2265
• ISSN: 0300-0664
• Language: English
• Keywords: Polymorphism, Genetic; Antigens, CD; CTLA-4 Antigen; Antigens, Differentiation; China; Genotype; Hypothyroidism; Lupus Erythematosus, Systemic; Immunoconjugates; Autoimmune Diseases; Graves Disease; Humans; Case-Control Studies; Promoter Regions, Genetic; Alleles; Hong Kong; Thyroid Diseases