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Journal article

ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect

Abstract:

Mitochondria form a highly dynamic network driven by opposing scission and fusion events. DRP1 is an essential modulator of mitochondrial fission and dynamics within mammalian cells. Its fission activity is regulated by posttranslational modifications such as activating phosphorylation at serine 616. DRP1 activity has recently been implicated as being dysregulated in numerous human disorders such as cancer and neurodegenerative diseases. Here we describe the development of a cellbased screeni...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.22264

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Simmons, A
Grant:
NIHR-RP-R3-12-026
More from this funder
Name:
Wellcome Trust
Funding agency for:
Simmons, A
Grant:
NIHR-RP-R3-12-026
Publisher:
Impact Journals
Journal:
Oncotarget More from this journal
Volume:
8
Issue:
63
Pages:
106764-106777
Publication date:
2017-11-01
Acceptance date:
2017-10-17
DOI:
ISSN:
1949-2553
Pubs id:
pubs:744112
UUID:
uuid:28b0f5ba-3d95-43f3-9d60-cbaba42a5b7d
Local pid:
pubs:744112
Deposit date:
2017-11-09

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