Heavy ions can enhance TGFβ mediated epithelial to mesenchymal transition.

Journal article

TGFβ is a key modulator of the Epithelial-Mesenchymal Transition (EMT), a process important in cancer progression and metastasis, which leads to the suppression of epithelial genes and expression of mesenchymal proteins. Ionizing radiation was found to specifically induce expression of the TGF-β1 isoform, which can modulate late post-radiation changes and increase the risk of tumor development and metastasis. Interactions between TGFβ induced EMT and DNA damage responses have not been fully e...

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Authors: Wang, M; Hada, M; Huff, J; Pluth, J; Anderson, J

• Publication status: Published
• Journal: Journal of radiation research
• Volume: 53
• Issue: 1
• Pages: 51-57
• Publication date: 2012-01-01
• DOI: 10.1269/jrr.11121
• EISSN: 1349-9157
• ISSN: 0449-3060
• Language: English
• Keywords: Recombinant Proteins; Pteridines; Mink; Animals; Iron; Dose-Response Relationship, Radiation; Protein-Serine-Threonine Kinases; Cell Line, Transformed; Epithelial Cells; Silicon; Receptors, Transforming Growth Factor beta; beta Catenin; Transforming Growth Factor beta1; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Esophagus; Protein Processing, Post-Translational; Humans; Phosphorylation; Lung; Smad7 Protein; Heavy Ions; Smad2 Protein