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Thesis

MicroRNA biogenesis and cytoophidia in Drosophila melanogaster

Abstract:

This thesis contains two separate projects. The first project involves the study of Argonaute 1 (Ago1) which is a member of the Argonaute/PIWI protein family involved in small RNA-mediated gene regulation. In Drosophila, Ago1 plays a specific role in microRNA (miRNA) function. Previous studies have demonstrated that Ago1 regulates the fate of germline stem cells. However, the function of Ago1 in other aspects of oogenesis is still elusive. Here, the function of Ago1 was analysed in the fem...

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Institution:
University of Oxford
Research group:
MRC Functional Genomics Uni
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
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Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Mohd Ghows Mohd Azzam
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral

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