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Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): An open-label, randomised trial

Abstract:

Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parenteral treatment with either artesunate or quinine in African children with severe malaria. This open-label, randomised trial was undertaken in 11 centres in nine African countries. Children (<15 yea...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
The Lancet
Volume:
376
Issue:
9753
Pages:
1647-1657
Publication date:
2010-11-13
DOI:
ISSN:
0140-6736
URN:
uuid:28a41832-95e6-4f03-82a9-bb3855f73486
Source identifiers:
102698
Local pid:
pubs:102698
Language:
English

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