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Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology

Abstract:

Type 2 diabetes (T2D) is a disease of pandemic proportions, one defined by a complex aetiological mix of genetic, epigenetic, environmental, and lifestyle risk factors. Whilst the last decade of T2D genetic research has identified more than 100 loci showing strong statistical association with disease susceptibility, our inability to capitalise upon these signals reflects, in part, a lack of appropriate human cell models for study. This review discusses the impact of two complementary, state-o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Gloyn, A
Grant:
Senior Fellow in Basic Biomedical Research (095101)
More from this funder
Name:
Naomi Berrie Fellow in Diabetes Research Award
Funding agency for:
Beer, N
Publisher:
F1000Research
Journal:
F1000Research More from this journal
Publication date:
2016-01-01
Acceptance date:
2016-07-15
DOI:
ISSN:
2046-1402
Pubs id:
pubs:642664
UUID:
uuid:2898f9de-3d4d-4139-9f32-3e49e4cac1b9
Local pid:
pubs:642664
Source identifiers:
642664
Deposit date:
2016-09-13

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