Transplantation tolerance in an age of induced pluripotency.
PURPOSE OF REVIEW: In a seminal paper in 2006, Yamanaka and coworkers reported the reprogramming of terminally differentiated murine cells to a pluripotent state, largely indistinguishable from conventional embryonic stem cells. The introduction of defined transcription factors via retroviral transduction revealed, in principle, how pluripotency, once thought to be lost at an early stage of embryogenesis, could be reawakened in adulthood. RECENT FINDINGS: Since these initial findings, induce...Expand abstract
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