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Quinine disposition kinetics.

Abstract:

Intravenous quinine dihydrochloride (5 mg kg-1 over 5 min) was given to seven healthy male volunteers. There were minor subjective symptoms in all subjects but no significant changes in pulse or blood pressure. There was significant prolongation of the electrocardiographic QRS and rate corrected QT intervals which was greatest between 1 and 4 min after completion of the quinine infusion. Values then returned towards baseline. Plasma concentrations of quinine were measured spectrophotofluorime...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Chanthavanich, P More by this author
Krishna, S More by this author
Silamut, K More by this author
Journal:
British journal of clinical pharmacology
Volume:
16
Issue:
4
Pages:
399-403
Publication date:
1983-10-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:2889da1a-8996-4062-a2bb-5387f2c361b5
Source identifiers:
42238
Local pid:
pubs:42238

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