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Whole Genome Sequencing reveals the contribution of long-term carriers in Staphylococcus aureus outbreak investigation

Abstract:

Whole genome sequencing (WGS) makes it possible to determine the relatedness of bacterial isolates at high resolution, helping to characterise outbreaks. However, for Staphylococcus aureus, accumulation of within-host diversity during carriage might limit interpretation of sequencing data. In this study, we hypothesised the converse: that within-host diversity can in fact be exploited to reveal the involvement of long-term carriers (LTCs) in outbreaks. We analysed WGS data from 20 historical ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/JCM.00363-17

Authors


Gordon, NC More by this author
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Health Innovation Challenge Fund More from this funder
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Grant:
Health Protection Research Unit (NIHR HPRU)
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Clinical Microbiology Journal website
Volume:
55
Issue:
7
Pages:
2188-2197
Publication date:
2017-05-03
Acceptance date:
2017-04-22
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
Pubs id:
pubs:691037
URN:
uri:2888e7c6-8b60-4fa1-97ba-799c8ea01d7c
UUID:
uuid:2888e7c6-8b60-4fa1-97ba-799c8ea01d7c
Local pid:
pubs:691037

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