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Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia.

Abstract:

Despite advances in the curative treatment of acute myeloid leukemia (AML), recurrence will occur in the majority of cases. At diagnosis, acquisition of segmental uniparental disomy (UPD) by mitotic recombination has been reported in 15% to 20% of AML cases, associated with homozygous mutations in the region of loss of heterozygosity. This study aimed to discover if clonal evolution from heterozygous to homozygous mutations by mitotic recombination provides a mechanism for relapse. DNA from 2...

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Authors


Raghavan, M More by this author
Lillington, DM More by this author
Chaplin, T More by this author
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Journal:
Blood
Volume:
112
Issue:
3
Pages:
814-821
Publication date:
2008-08-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:28873fc9-b50b-4072-80f5-99996c9ffa48
Source identifiers:
292236
Local pid:
pubs:292236

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