Journal article

Themis2 lowers the threshold for B cell activation during positive selection

Abstract:: The positive and negative selection of lymphocytes by antigen is central to adaptive immunity and self-tolerance, yet how this is determined by different antigens is incompletely understood. Here we report that Themis2 increased the positive selection of B1 cells and germinal center B cells by self and foreign antigens. We found that Themis2 lowered the threshold for B cell activation by low but not high avidity antigens. Themis2 constitutively bound the adaptor protein Grb2, src-kinase Lyn a...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Cornall, R., Deobagkar-Lele, M., Cheng, D., Zvezdova, E., Choi, S., Uehara, S., Baup, D., Bull, K., Crockford, T., Bennett, S., Ferry, H., Warzecha, C., Marcellin, M., Gonzalez de Peredo, A., Lesourne, R., Anzilotti, C., & Love, P. (2016). Themis2 lowers the threshold for B cell activation during positive selection. Nature Immunology, 18, 205–213.

MLA Style

Cornall, R., et al. “Themis2 Lowers the Threshold for B Cell Activation during Positive Selection.” Nature Immunology, vol. 18, Nature Publishing Group, 2016, pp. 205–13.

Chicago Style

Cornall, R, M Deobagkar-Lele, D Cheng, E Zvezdova, S Choi, S Uehara, D Baup, et al. 2016. “Themis2 Lowers the Threshold for B Cell Activation during Positive Selection.” Nature Immunology 18: 205–13.
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Cornall et al, Themis2 lowers the threshold for B cell activat...

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Supplementary material for Cornall et al, Themis2 lowers the t...

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Publisher copy:: 10.1038/ni.3642

Authors

+ Cornall, R More by this author

Institution:

University of Oxford

Oxford college:

Corpus Christi College

Role:

Author

+ Deobagkar-Lele, M More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Cheng, D More by this author

Role:

Author

+ Zvezdova, E More by this author

Role:

Author

+ Choi, S More by this author

Role:

Author

More authors...

Funding

+ Eunice Kennedy Shriver National Institute of Child Health and Human Development More from this funder

Grant:

1ZIAHD001803-19

+ Wellcome Trust More from this funder

+ Medical Research Council More from this funder

Bibliographic Details

Publisher:: Nature Publishing Group
Journal:: Nature Immunology More from this journal
Volume:: 18
Pages:: 205-213
Publication date:: 2016-12-01
Acceptance date:: 2016-11-22
DOI:: 10.1038/ni.3642
EISSN:: 1529-2916
ISSN:: 1529-2908

Item Description

Pubs id:: pubs:662040
UUID:: uuid:2883e509-f441-4bc6-afab-46dd5337fde3
Local pid:: pubs:662040
Source identifiers:: 662040
Deposit date:: 2016-11-29

Terms of use

Copyright holder:: Nature America, Inc
Copyright date:: 2016
Notes:: © 2016 Nature America, Inc, part of Springer Nature

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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