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Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development.

Abstract:

BACKGROUND: Synthetic probes that mimic natural substrates can enable the detection of enzymatic activities in a cellular environment. One area where such activity-based probes have been applied is the ubiquitin-proteasome pathway, which is emerging as an important therapeutic target. A family of reagents has been developed that specifically label deubiquitylating enzymes (DUBs) and facilitate characterization of their inhibitors. SCOPE OF REVIEW: Here we focus on the application of probes fo...

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Publication status:
Published

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Authors


Kramer, HB More by this author
Nicholson, B More by this author
Kessler, BM More by this author
Journal:
Biochimica et biophysica acta
Volume:
1823
Issue:
11
Pages:
2029-2037
Publication date:
2012-11-05
DOI:
EISSN:
1879-2596
ISSN:
0006-3002
URN:
uuid:28821d2e-24eb-4ce1-998b-3ee951c7132f
Source identifiers:
332742
Local pid:
pubs:332742

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