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Journal article

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.

Abstract:

Collagenases of the matrix metalloproteinase (MMP) family play major roles in morphogenesis, tissue repair, and human diseases, but how they recognize and cleave the collagen triple helix is not fully understood. Here, we report temperature-dependent binding of a catalytically inactive MMP-1 mutant (E200A) to collagen through the cooperative action of its catalytic and hemopexin domains. Contact between the two molecules was mapped by screening the Collagen Toolkit peptide library and by hydr...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1204991109

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
31
Pages:
12461-12466
Publication date:
2012-07-03
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
341201
Language:
English
Keywords:
Pubs id:
pubs:341201
UUID:
uuid:2841fab0-13c7-4187-b871-231ac214ded3
Local pid:
pubs:341201
Deposit date:
2012-12-19

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