Journal article
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.
- Abstract:
-
Collagenases of the matrix metalloproteinase (MMP) family play major roles in morphogenesis, tissue repair, and human diseases, but how they recognize and cleave the collagen triple helix is not fully understood. Here, we report temperature-dependent binding of a catalytically inactive MMP-1 mutant (E200A) to collagen through the cooperative action of its catalytic and hemopexin domains. Contact between the two molecules was mapped by screening the Collagen Toolkit peptide library and by hydr...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.1204991109
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Authors
Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 109
- Issue:
- 31
- Pages:
- 12461-12466
- Publication date:
- 2012-07-03
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
341201
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:341201
- UUID:
-
uuid:2841fab0-13c7-4187-b871-231ac214ded3
- Local pid:
- pubs:341201
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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