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Thesis

One-pot nitro-Mannich cascade reactions: new methodologies and synthetic applications

Abstract:

Pyrrolidine and pyrrolidinone rings are common motifs found in many biologically active natural products and drugs. Accordingly, our work focuses on the development of new methodologies for their one-pot synthesis.

An efficient diastereoselective nitro-Mannich / lactamisation reaction cascade of methyl 3-nitropropanoate with cyclic and acyclic imines for the direct preparation of trans-monocyclic and fused tricyclic pyrrolidinone derivatives was developed. The reaction is easy to pe...

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Institution:
University of Oxford
Research group:
Prof. Darren Dixon
Oxford college:
Wadham College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Sophie Marie-Clémentine Pelletier
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:283641bf-bb4e-48a8-8a28-2e048b8c4ea6
Local pid:
ora:6900

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