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Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition.

Abstract:

The cyclic nucleotides cAMP and cGMP are common signaling molecules synthesized in neurons following the activation of adenylyl or guanylyl cyclase. In the striatum, the synthesis and degradation of cAMP and cGMP is highly regulated as these second messengers have potent effects on the activity of striatonigral and striatopallidal neurons. This review will summarize the literature on cyclic nucleotide signaling in the striatum with a particular focus on the impact of cAMP and cGMP on the memb...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.baga.2013.08.001

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Elsevier
Journal:
Basal ganglia More from this journal
Volume:
3
Issue:
3
Pages:
137-146
Publication date:
2013-12-01
DOI:
EISSN:
2210-5336
ISSN:
2210-5336
Language:
English
Keywords:
Pubs id:
pubs:443201
UUID:
uuid:28198442-c9f2-4390-8f15-88bd2dc66436
Local pid:
pubs:443201
Source identifiers:
443201
Deposit date:
2014-09-22

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