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Mesenchymal stem cell treatment of intervertebral disc lesion prevents fatty infiltration and fibrosis of the multifidus muscle, but not cytokine and muscle fiber changes

Abstract:

Study Design: Longitudinal case-control animal model.
Objective: To investigate effects of mesenchymal stem cell (MSC) treatment on multifidus muscle remodeling after intervertebral disc (IVD) lesion.
Summary of Background Data: Lesion and degeneration of IVDs cause structural remodeling of the multifidus muscle. Proinflammatory cytokines are thought to contribute. MSC treatment restores IVD health after lesion but its effects on...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1097/BRS.0000000000001669

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
Spine Journal website
Volume:
41
Issue:
15
Pages:
1208-1217
Publication date:
2016-08-01
Acceptance date:
2016-02-16
DOI:
EISSN:
1528-1159
ISSN:
0362-2436
Pubs id:
pubs:619574
URN:
uri:28135148-aa44-43e8-be2e-c4da0346cac2
UUID:
uuid:28135148-aa44-43e8-be2e-c4da0346cac2
Local pid:
pubs:619574

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