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The role of the DNA sliding clamp in Okazaki fragment maturation in archaea and eukaryotes.

Abstract:

Efficient processing of Okazaki fragments generated during discontinuous lagging-strand DNA replication is critical for the maintenance of genome integrity. In eukaryotes, a number of enzymes co-ordinate to ensure the removal of initiating primers from the 5'-end of each fragment and the generation of a covalently linked daughter strand. Studies in eukaryotic systems have revealed that the co-ordination of DNA polymerase δ and FEN-1 (Flap Endonuclease 1) is sufficient to remove the majority o...

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Publication status:
Published

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Publisher copy:
10.1042/bst0390070

Authors


Beattie, TR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Biochemical Society transactions
Volume:
39
Issue:
1
Pages:
70-76
Publication date:
2011-01-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:2812f8b7-a5f4-4166-a5ec-dd60379c761d
Source identifiers:
115724
Local pid:
pubs:115724

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