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GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats.

Abstract:

Nitric oxide (NO) synthesis in endothelial cells is impaired in diabetes. We previously showed that impaired NO synthesis in the spontaneously diabetic BB (BBd) rat is due to decreased levels of tetrahydrobiopterin (BH4), secondary to decreased expression of GTP cyclohydrolase I (GTPCH). The aim of this study was to utilize adenoviral GTPCH gene transfer to reverse BH4 deficiency and repair the ability of endothelial cells to produce NO. GTPCH gene transfer increased BH4 levels in BBd endothe...

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Publication status:
Published

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Publisher copy:
10.1096/fj.04-1702fje

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
18
Issue:
15
Pages:
1900-1902
Publication date:
2004-12-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Source identifiers:
105145
Language:
English
Keywords:
Pubs id:
pubs:105145
UUID:
uuid:2803f535-8961-49a2-b299-b1babbba1379
Local pid:
pubs:105145
Deposit date:
2012-12-19

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