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Induction and abrogation of LACK reactive cells in the evolution of human leishmaniasis.

Abstract:

Peripheral blood mononuclear cells (PBMC) from cutaneous leishmaniasis patients with ongoing Leishmania aethiopica infection and individuals cured/under treatment from L. infantum or L. donovani infection were stimulated in vitro with LACK, the Leishmania homologue of receptors for activated C kinase. The LACK protein is conserved in related leishmanial species and is expressed both in the promastigote and amastigote stages of Leishmania. Our results show that LACK induced marked NK and some ...

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Publication status:
Published

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Authors


Söderström, K More by this author
Britton, S More by this author
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Journal:
Clinical and experimental immunology
Volume:
124
Issue:
2
Pages:
255-261
Publication date:
2001-05-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:2803f1d3-0248-4962-8e38-6b72a3826096
Source identifiers:
434244
Local pid:
pubs:434244

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