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Stage 2 registered report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: testing the double hit hypothesis

Abstract:
Background: The presence of an extra sex chromosome is associated with an increased rate of neurodevelopmental difficulties involving language. The 'double hit' hypothesis proposes that the adverse impact of the extra sex chromosome is amplified when genes that are expressed from the sex chromosomes interact with autosomal variants that usually have only mild effects. We predicted that the impact of an additional sex chromosome on neurodevelopment would depend on common autos... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.12688/wellcomeopenres.14677.2

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ORCID:
0000-0002-9557-268X
Simpson, N More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
ORCID:
0000-0001-9940-6913
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
Oxford college:
St Johns College
ORCID:
0000-0002-2448-4033
Publisher:
F1000Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
3
Issue:
85
Publication date:
2018-07-19
Acceptance date:
2018-07-19
DOI:
EISSN:
2398-502X
Pubs id:
pubs:911942
URN:
uri:27f9a1b3-e4a1-470b-a290-cd732846f021
UUID:
uuid:27f9a1b3-e4a1-470b-a290-cd732846f021
Local pid:
pubs:911942

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