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Stage 2 registered report: variation in neurodevelopmental outcomes in children with sex chromosome trisomies: testing the double hit hypothesis

Abstract:
Background: The presence of an extra sex chromosome is associated with an increased rate of neurodevelopmental difficulties involving language. The 'double hit' hypothesis proposes that the adverse impact of the extra sex chromosome is amplified when genes that are expressed from the sex chromosomes interact with autosomal variants that usually have only mild effects. We predicted that the impact of an additional sex chromosome on neurodevelopment would depend on common autos... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.12688/wellcomeopenres.14677.4

Authors


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Role:
Author
ORCID:
0000-0002-9557-268X
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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
ORCID:
0000-0001-9940-6913
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Institution:
University of Oxford
Department:
Experimental Psychology
Oxford college:
St John's College
Role:
Author
ORCID:
0000-0002-2448-4033
Publisher:
F1000Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
3
Issue:
85
Publication date:
2018-07-19
Acceptance date:
2018-07-19
DOI:
EISSN:
2398-502X
Source identifiers:
911942
Language:
English
Keywords:
Pubs id:
pubs:911942
UUID:
uuid:27f9a1b3-e4a1-470b-a290-cd732846f021
Local pid:
pubs:911942
Deposit date:
2018-09-17

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