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Pharmacometric and electrocardiographic evaluation of chloroquine and azithromycin in healthy volunteers

Abstract:

Chloroquine and azithromycin were developed in combination for the preventive treatment of malaria in pregnancy, and more recently were proposed as coronavirus disease 2019 (COVID-19) treatment options. Billions of doses of chloroquine have been administered worldwide over the past 70 years but concerns regarding cardiotoxicity, notably the risk of torsades de pointes (TdP), remain. This investigation aimed to characterize the pharmacokinetics and electrocardiographic effects of chloroquine a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cpt.2665

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
MORU Mahidol Oxford Tropical Medicine Research Unit
Role:
Author
ORCID:
0000-0003-3839-9777
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Centre for Tropical Medicine and Global Health at Oxford; MORU Mahidol Oxford Tropical Medicine Research Unit
Role:
Author
ORCID:
0000-0003-4566-4030
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Centre for Tropical Medicine and Global Health at Oxford; MORU Mahidol Oxford Tropical Medicine Research Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Centre for Tropical Medicine and Global Health at Oxford; MORU Mahidol Oxford Tropical Medicine Research Unit
Role:
Author
ORCID:
0000-0001-5524-0325
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Research group:
Centre for Tropical Medicine and Global Health at Oxford; MORU Mahidol Oxford Tropical Medicine Research Unit
Role:
Author
ORCID:
0000-0002-1897-1978
Publisher:
American Society for Clinical Pharmacology and Therapeutics
Journal:
Clinical Pharmacology & Therapeutics More from this journal
Volume:
112
Issue:
4
Pages:
824-835
Place of publication:
United States
Publication date:
2022-05-22
Acceptance date:
2022-05-10
DOI:
EISSN:
1532-6535
ISSN:
0009-9236
Pmid:
35598114

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