Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom.

Journal article

The cytotoxic T-lymphocyte-associated-4 (CTLA-4) molecule plays an important role in immune regulation by downregulating activation of T cells by antigen-presenting cells. Polymorphisms of the CTLA-4 gene have been shown to be associated with susceptibility to a number of autoimmune diseases. Some, but not all, studies suggest association between the CTLA-4 gene and autoimmune hypothyroidism. The aim of this study was to determine whether allelic association was present between the A-G single...

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Authors: Nithiyananthan, R; Heward, J; Allahabadia, A; Franklyn, J; Gough, S

• Journal: Thyroid : official journal of the American Thyroid Association
• Volume: 12
• Issue: 1
• Pages: 3-6
• Publication date: 2002-01-01
• DOI: 10.1089/105072502753451896
• EISSN: 1557-9077
• ISSN: 1050-7256
• Language: English
• Keywords: Polymorphism, Genetic; Antigens, Differentiation; Great Britain; Hypothyroidism; Exons; Humans; Polymerase Chain Reaction; Autoimmune Diseases; Antigens, CD; Polymorphism, Restriction Fragment Length; Chromosomes, Human, Pair 2; Genetic Predisposition to Disease; Genotype; Immunoconjugates; CTLA-4 Antigen