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Journal article

A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta.

Abstract:

The helix-loop-helix transcription factor TFE3 has been suggested to play a role in the control of cell growth by acting as a binding partner of transcriptional regulators such as E2F3, SMAD3, and LEF-1. Furthermore, translocations/TFE3 fusions have been directly implicated in tumorigenesis. Surprisingly, however, a direct functional role for TFE3 in the regulation of proliferation has not been reported. By screening retroviral cDNA expression libraries to identify cDNAs that confer resistanc...

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Publisher copy:
10.1074/jbc.m602312200

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
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Journal:
The Journal of biological chemistry
Volume:
281
Issue:
31
Pages:
21582-21587
Publication date:
2006-08-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:27ecce6a-6fe1-40c2-98f4-b576716da2a9
Source identifiers:
489981
Local pid:
pubs:489981

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