- Abstract:
-
We describe a novel method for assessing the strength of disease association with single nucleotide polymorphisms (SNPs) in a candidate gene or small candidate region, and for estimating the corresponding haplotype relative risks of disease, using unphased genotype data directly. We begin by estimating the relative frequencies of haplotypes consistent with observed SNP genotypes. Under the Bayesian partition model, we specify cluster centres from this set of consistent SNP haplotypes. The rem...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/gepi.20080
-
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- Journal:
- Genetic epidemiology
- Volume:
- 29
- Issue:
- 2
- Pages:
- 91-107
- Publication date:
- 2005-09-05
- DOI:
- EISSN:
-
1098-2272
- ISSN:
-
0741-0395
- URN:
-
uuid:27e6e807-3c21-45af-ae30-bdaf9788868b
- Source identifiers:
-
33131
- Local pid:
- pubs:33131
- Copyright date:
- 2005
Journal article
Direct analysis of unphased SNP genotype data in population-based association studies via Bayesian partition modelling of haplotypes.
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