Journal article
Direct analysis of unphased SNP genotype data in population-based association studies via Bayesian partition modelling of haplotypes.
- Abstract:
-
We describe a novel method for assessing the strength of disease association with single nucleotide polymorphisms (SNPs) in a candidate gene or small candidate region, and for estimating the corresponding haplotype relative risks of disease, using unphased genotype data directly. We begin by estimating the relative frequencies of haplotypes consistent with observed SNP genotypes. Under the Bayesian partition model, we specify cluster centres from this set of consistent SNP haplotypes. The rem...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/gepi.20080
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Authors
Bibliographic Details
- Journal:
- Genetic epidemiology
- Volume:
- 29
- Issue:
- 2
- Pages:
- 91-107
- Publication date:
- 2005-09-01
- DOI:
- EISSN:
-
1098-2272
- ISSN:
-
0741-0395
- Source identifiers:
-
33131
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:33131
- UUID:
-
uuid:27e6e807-3c21-45af-ae30-bdaf9788868b
- Local pid:
- pubs:33131
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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