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Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation.

Abstract:
Building with PEGs: PEG-boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70-98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands. © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

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Publisher copy:
10.1002/anie.201208626

Authors


Spicer, CD More by this author
Takehana, T More by this author
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Journal:
Angewandte Chemie (International ed. in English)
Volume:
52
Issue:
14
Pages:
3916-3921
Publication date:
2013-04-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:27d6818c-17a5-4103-8825-4b7a90b38693
Source identifiers:
387104
Local pid:
pubs:387104

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