- Building with PEGs: PEG-boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70-98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands. © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
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Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation.
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