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Journal article

Discoidin domain receptors: Microenvironment sensors that promote cellular migration and invasion

Subtitle:
Commentary
Abstract:

Extracellular matrix (ECM) provides cells scaffolding for cell migration and microenvironment for various cellular functions. Collagens are major ECM components in tissue and discoidin domain receptors (DDRs) are receptor tyrosine kinases (RTK) that recognise fibrillar collagens. Unlike other RTK, their ligands are solid ECM the that are abundantly present in the pericellular environment in various tissue, and thus its activation and regulations are unique amongst RTK family. It is emerging t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/19336918.2018.1460011

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Role:
Author
Publisher:
Taylor & Francis Publisher's website
Journal:
Cell Adhesion and Migration Journal website
Volume:
12
Issue:
4
Pages:
378-385
Publication date:
2018-05-08
Acceptance date:
2018-03-26
DOI:
EISSN:
1933-6926
ISSN:
1933-6918
Pubs id:
pubs:842281
URN:
uri:27c2ffc9-b8fc-4752-bed0-2a9d9c61f580
UUID:
uuid:27c2ffc9-b8fc-4752-bed0-2a9d9c61f580
Local pid:
pubs:842281

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