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Journal article

Atypical E2F activity restrains APC/CCCS52A2 function obligatory for endocycle onset.

Abstract:

The endocycle represents an alternative cell cycle that is activated in various developmental processes, including placental formation, Drosophila oogenesis, and leaf development. In endocycling cells, mitotic cell cycle exit is followed by successive doublings of the DNA content, resulting in polyploidy. The timing of endocycle onset is crucial for correct development, because polyploidization is linked with cessation of cell division and initiation of terminal differentiation. The anaphase-...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0806510105

Authors


Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
105
Issue:
38
Pages:
14721-14726
Publication date:
2008-09-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:261982
UUID:
uuid:27bcae33-8728-45ef-aa6e-be0afcc8e011
Local pid:
pubs:261982
Source identifiers:
261982
Deposit date:
2012-12-19

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