Activation of latent proteinases ensures that the timing of proteolysis is regulated precisely, a process that generally involves proteolytic excision of a pro-region or a tightly bound inhibitor. Here we define the activation mechanism for Lit, a dormant suicide proteinase in Escherichia coli K-12. Previous work has shown that Gol, a short sequence within the major capsid protein gp23, activates Lit during the latter stages of T4 phage infection. This results in cell death and exclusion of t...Expand abstract
- Publisher copy:
- Copyright date:
The role of an activating peptide in protease-mediated suicide of Escherichia coli K12.
If you are the owner of this record, you can report an update to it here: Report update to this record