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The role of an activating peptide in protease-mediated suicide of Escherichia coli K12.

Abstract:

Activation of latent proteinases ensures that the timing of proteolysis is regulated precisely, a process that generally involves proteolytic excision of a pro-region or a tightly bound inhibitor. Here we define the activation mechanism for Lit, a dormant suicide proteinase in Escherichia coli K-12. Previous work has shown that Gol, a short sequence within the major capsid protein gp23, activates Lit during the latter stages of T4 phage infection. This results in cell death and exclusion of t...

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Publisher copy:
10.1074/jbc.m411280200

Authors


Copeland, NA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
The Journal of biological chemistry
Volume:
280
Issue:
1
Pages:
112-117
Publication date:
2005-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:27b176d3-21a1-4b9e-b0ad-b9219388fce4
Source identifiers:
310191
Local pid:
pubs:310191

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