Journal article

Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors

Abstract:: Antimicrobial resistance is a pressing threat to global health, with multidrug-resistant pathogens becoming increasingly prevalent. The bacterial SOS pathway functions in response to DNA damage that occurs during infection, initiating several pro-survival and resistance mechanisms, such as DNA repair and hypermutation. This makes SOS pathway components potential targets that may combat drug-resistant pathogens and decrease resistance emergence. This review discusses the mechanism of the SOS pathway; the structure and function of potential targets AddAB, RecBCD, RecA and LexA; and efforts to develop selective small-molecule inhibitors of these proteins. These inhibitors may serve as valuable tools for target validation and provide the foundations for desperately needed novel antibacterial therapeutics.

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Lanyon-Hogg, T. (2021). Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors. Future Medicinal Chemistry, 13(2), 143–155.

MLA Style

Lanyon-Hogg, T. “Targeting the Bacterial SOS Response for New Antimicrobial Agents: Drug Targets, Molecular Mechanisms and Inhibitors.” Future Medicinal Chemistry, vol. 13, no. 2, Future Science, 2021, pp. 143–55.

Chicago Style

Lanyon-Hogg, T. 2021. “Targeting the Bacterial SOS Response for New Antimicrobial Agents: Drug Targets, Molecular Mechanisms and Inhibitors.” Future Medicinal Chemistry 13 (2): 143–55.
Share
Print

Access Document

Files:: Lanyon_Hogg_2021_targeting_the_bacterial.pdf

(Preview, Accepted manuscript, 693.0KB, Terms of use)

Publisher copy:: 10.4155/fmc-2020-0310

Authors

+ Lanyon-Hogg, T More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Pharmacology
Role:: Author
ORCID:: 0000-0002-7092-8096

Publisher:: Future Science
Journal:: Future Medicinal Chemistry More from this journal
Volume:: 13
Issue:: 2
Pages:: 143-155
Publication date:: 2021-01-07
Acceptance date:: 2020-12-04
DOI:: 10.4155/fmc-2020-0310
EISSN:: 1756-8927
ISSN:: 1756-8919
Pmid:: 33410707

Language:: English
Keywords:: drug discovery

FFR

SOS response

antimicrobial resistance
Pubs id:: 1152612
Local pid:: pubs:1152612
Deposit date:: 2021-03-24

Terms of use

Copyright holder:: Newlands Press
Copyright date:: 2021
Rights statement:: © 2021 Newlands Press
Notes:: This is the accepted manuscript version of the article. The final version is available online from Future Science at: https://doi.org/10.4155/fmc-2020-0310

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP