Therapeutic efficacy of erythrpoietin in experimental autoimmune encephalomyelitis in mice, a model of multiple sclerosis

Journal article

Erythropoietin (EPO) has neuroprotective effects in many models of damage and disease of the nervous system where neuroinflammation plays a substantial role, including experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). Since thefirst pioneering studies, in which EPO was shown to protect rats with acute EAE mainly by inhibiting inflammation, many other studies have pointed out other mechanisms of protection, including oligodendrogenesis and inhibition...

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Authors: Cervellini, I; Ghezzi, P; Mengozzi, M

• Journal: Methods in Molecular Biology
• Volume: 982
• Pages: 163-173
• Publication date: 2013-01-01
• DOI: 10.1007/978-1-62703-308-4-10
• ISSN: 1064-3745
• Language: English
• Keywords: Myelin oligodendrocyte glycoprotein; Neuroprotection; Demyelination; Animal model; Neuroinflammation