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Therapeutic efficacy of erythrpoietin in experimental autoimmune encephalomyelitis in mice, a model of multiple sclerosis

Abstract:

Erythropoietin (EPO) has neuroprotective effects in many models of damage and disease of the nervous system where neuroinflammation plays a substantial role, including experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). Since thefirst pioneering studies, in which EPO was shown to protect rats with acute EAE mainly by inhibiting inflammation, many other studies have pointed out other mechanisms of protection, including oligodendrogenesis and inhibition...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Mengozzi, M More by this author
Journal:
Methods in Molecular Biology
Volume:
982
Pages:
163-173
Publication date:
2013
DOI:
ISSN:
1064-3745
URN:
uuid:27aaccd8-2bba-477b-8dca-343d7e7eb75e
Source identifiers:
470793
Local pid:
pubs:470793

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