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Optimal CD4 count for initiating HIV treatment: impact of CD4 observation frequency and grace periods, and performance of dynamic marginal structural models.

Abstract:

BACKGROUND: In HIV infection, dynamic marginal structural models have estimated the optimal CD4 for treatment initiation to minimize AIDS/death. The impact of CD4 observation frequency and grace periods (permitted delay to initiation) on the optimal regimen has not been investigated nor has the performance of dynamic marginal structural models in moderately sized data sets-two issues that are relevant to many applications. METHODS: To determine optimal regimens, we simulated 31,000,000 HIV-in...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Epidemiology (Cambridge, Mass.)
Volume:
25
Issue:
2
Pages:
194-202
Publication date:
2014-03-05
DOI:
EISSN:
1531-5487
ISSN:
1044-3983
URN:
uuid:2794c5b0-c511-487a-80e6-60c96041d00d
Source identifiers:
452005
Local pid:
pubs:452005

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